Symptoms of Parkinson's disease have been known and treated since medieval times, most notably by Averroes.
However, it was not formally recognized and its symptoms were not documented until 1817 in ''An Essay on the Shaking Palsy''
by the British physician James Parkinson. Parkinson's disease was then known as ''paralysis agitans'', the term "Parkinson's disease" being coined later by Jean-Martin Charcot.
The underlying biochemical changes in the brain were identified in the 1950s due largely to the work of Swedish scientist Arvid Carlsson, who later went on to win a Nobel Prize. L-dopa entered clinical practice in 1967, and the first large study reporting improvements in patients with Parkinson's disease resulting from treatment with L-dopa was published in 1968.
